Drug interactions
Pentobarbital + Quinine
Severity: Moderate
Pentobarbital and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and can substantially lower quinine concentrations. This risks treatment failure in malaria and reduced effect in other uses.
What this interaction means in plain words
Pentobarbital and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pentobarbital induces hepatic CYP3A4, accelerating quinine clearance.
What to do
Avoid the combination where possible. If both are required, monitor treatment response closely and consider an alternative antimalarial.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Pentobarbital with Quinine?
MediHelp rates the interaction as moderate. Pentobarbital and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and can substantially lower quinine concentrations. This risks treatment failure in malaria and reduced effect in other uses.
How serious is the interaction between Pentobarbital and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are required, monitor treatment response closely and consider an alternative antimalarial.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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