Drug interactions
Pentobarbital + Tadalafil
Severity: Moderate
Pentobarbital and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces CYP3A4 and may reduce tadalafil exposure. This can cause reduced efficacy, which matters most in pulmonary arterial hypertension.
What this interaction means in plain words
Pentobarbital and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated CYP3A4 induction increases tadalafil metabolism.
What to do
Avoid the combination in pulmonary arterial hypertension. In erectile dysfunction, monitor response and adjust the tadalafil dose or choose an alternative if effect is insufficient.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Pentobarbital with Tadalafil?
MediHelp rates the interaction as moderate. Pentobarbital and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital induces CYP3A4 and may reduce tadalafil exposure. This can cause reduced efficacy, which matters most in pulmonary arterial hypertension.
How serious is the interaction between Pentobarbital and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in pulmonary arterial hypertension. In erectile dysfunction, monitor response and adjust the tadalafil dose or choose an alternative if effect is insufficient.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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