Drug interactions
Pentobarbital + Timolol
Severity: Moderate
Pentobarbital and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces hepatic enzymes and can lower plasma concentrations of beta-blockers that are metabolized by the liver, including timolol. The result may be reduced heart rate and blood pressure control.
What this interaction means in plain words
Pentobarbital and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of hepatic CYP enzymes increases the metabolic clearance of timolol.
What to do
Monitor heart rate and blood pressure when starting or stopping pentobarbital and increase the timolol dose if needed; reduce it again when the barbiturate is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Pentobarbital with Timolol?
MediHelp rates the interaction as moderate. Pentobarbital and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital induces hepatic enzymes and can lower plasma concentrations of beta-blockers that are metabolized by the liver, including timolol. The result may be reduced heart rate and blood pressure control.
How serious is the interaction between Pentobarbital and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping pentobarbital and increase the timolol dose if needed; reduce it again when the barbiturate is withdrawn.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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