Drug interactions
Peramivir + Tobramycin
Severity: Moderate
Peramivir and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peramivir is eliminated renally, and tobramycin is nephrotoxic. Kidney injury from tobramycin could raise peramivir exposure and increase adverse effects.
What this interaction means in plain words
Peramivir and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aminoglycoside nephrotoxicity may reduce renal clearance of peramivir.
What to do
Monitor serum creatinine and adjust the peramivir dose according to renal function. Check tobramycin levels as usual.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Peramivir with Tobramycin?
MediHelp rates the interaction as moderate. Peramivir and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Peramivir is eliminated renally, and tobramycin is nephrotoxic. Kidney injury from tobramycin could raise peramivir exposure and increase adverse effects.
How serious is the interaction between Peramivir and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and adjust the peramivir dose according to renal function. Check tobramycin levels as usual.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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