Drug interactions
Perindopril + Promethazine
Severity: Minor
Perindopril and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine can cause orthostatic hypotension through alpha-adrenergic blockade, which may add to the blood pressure lowering of perindopril. The effect is usually small but may matter in older or volume-depleted patients.
What this interaction means in plain words
Perindopril and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Perindopril belongs to Cardiovascular; Promethazine belongs to Respiratory.
Why it happens
Additive hypotensive effect from alpha-blockade by promethazine and ACE inhibition.
What to do
Monitor blood pressure and ask about dizziness when promethazine is started. Advise patients to rise slowly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Perindopril with Promethazine?
MediHelp rates the interaction as minor. Perindopril and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promethazine can cause orthostatic hypotension through alpha-adrenergic blockade, which may add to the blood pressure lowering of perindopril. The effect is usually small but may matter in older or volume-depleted patients.
How serious is the interaction between Perindopril and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ask about dizziness when promethazine is started. Advise patients to rise slowly.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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