Drug interactions
Phendimetrazine + Phenelzine
Severity: Contraindicated
Phendimetrazine and Phenelzine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic that releases norepinephrine and dopamine. With an MAOI it can cause hypertensive crisis. Labeling contraindicates use during or shortly after MAOI therapy.
What this interaction means in plain words
Phendimetrazine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Amphetamine-like catecholamine release is potentiated by irreversible MAO inhibition.
What to do
Do not combine; avoid phendimetrazine for at least 14 days after stopping phenelzine. Use non-sympathomimetic weight management options.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Phendimetrazine with Phenelzine?
MediHelp rates the interaction as contraindicated. Phendimetrazine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phendimetrazine is a sympathomimetic anorectic that releases norepinephrine and dopamine. With an MAOI it can cause hypertensive crisis. Labeling contraindicates use during or shortly after MAOI therapy.
How serious is the interaction between Phendimetrazine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; avoid phendimetrazine for at least 14 days after stopping phenelzine. Use non-sympathomimetic weight management options.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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