Drug interactions
Phendimetrazine + Rasagiline
Severity: Contraindicated
Phendimetrazine and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic that is contraindicated with MAO inhibitors. The combination can provoke a hypertensive crisis with severe headache, arrhythmia or stroke.
What this interaction means in plain words
Phendimetrazine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition prevents breakdown of catecholamines, and indirect sympathomimetics release more norepinephrine, producing exaggerated pressor responses.
What to do
Do not use together or within 14 days of stopping an MAO inhibitor. Choose a non-pharmacologic or alternative weight-management approach.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Phendimetrazine with Rasagiline?
MediHelp rates the interaction as contraindicated. Phendimetrazine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phendimetrazine is a sympathomimetic anorectic that is contraindicated with MAO inhibitors. The combination can provoke a hypertensive crisis with severe headache, arrhythmia or stroke.
How serious is the interaction between Phendimetrazine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping an MAO inhibitor. Choose a non-pharmacologic or alternative weight-management approach.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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