Drug interactions
Phendimetrazine + Safinamide
Severity: Contraindicated
Phendimetrazine and Safinamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic that releases catecholamines. With an MAO inhibitor, there is a risk of hypertensive crisis and serotonin-like toxicity.
What this interaction means in plain words
Phendimetrazine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition prevents breakdown of monoamines released by phendimetrazine, producing additive adrenergic effects.
What to do
Avoid the combination and allow at least 14 days after stopping safinamide before using phendimetrazine. Use non-pharmacologic or non-sympathomimetic weight management.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Phendimetrazine with Safinamide?
MediHelp rates the interaction as contraindicated. Phendimetrazine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phendimetrazine is a sympathomimetic anorectic that releases catecholamines. With an MAO inhibitor, there is a risk of hypertensive crisis and serotonin-like toxicity.
How serious is the interaction between Phendimetrazine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and allow at least 14 days after stopping safinamide before using phendimetrazine. Use non-pharmacologic or non-sympathomimetic weight management.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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