Drug interactions
Phendimetrazine + Salmeterol
Severity: Moderate
Phendimetrazine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic and combined with salmeterol may add to heart rate and blood pressure elevation, palpitations and tremor. Patients with cardiovascular disease are most at risk.
What this interaction means in plain words
Phendimetrazine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic (adrenergic) stimulation.
What to do
Monitor heart rate and blood pressure and ask about palpitations; avoid the combination in patients with uncontrolled hypertension or arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Phendimetrazine with Salmeterol?
MediHelp rates the interaction as moderate. Phendimetrazine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phendimetrazine is a sympathomimetic anorectic and combined with salmeterol may add to heart rate and blood pressure elevation, palpitations and tremor. Patients with cardiovascular disease are most at risk.
How serious is the interaction between Phendimetrazine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and ask about palpitations; avoid the combination in patients with uncontrolled hypertension or arrhythmia.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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