Drug interactions
Phendimetrazine + Selegiline
Severity: Contraindicated
Phendimetrazine and Selegiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic, and with MAO inhibitors may cause hypertensive crisis. Labeling contraindicates its use during or within 14 days of MAOI therapy.
What this interaction means in plain words
Phendimetrazine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Phendimetrazine releases norepinephrine, and MAO inhibition blocks its breakdown, so it accumulates.
What to do
Avoid the combination and leave at least 14 days after stopping the MAOI. Choose a non-stimulant weight management approach.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Phendimetrazine with Selegiline?
MediHelp rates the interaction as contraindicated. Phendimetrazine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phendimetrazine is a sympathomimetic anorectic, and with MAO inhibitors may cause hypertensive crisis. Labeling contraindicates its use during or within 14 days of MAOI therapy.
How serious is the interaction between Phendimetrazine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and leave at least 14 days after stopping the MAOI. Choose a non-stimulant weight management approach.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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