Drug interactions
Phenelzine + Pirbuterol
Severity: Major
Phenelzine and Pirbuterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenelzine can potentiate the cardiovascular effects of sympathomimetic beta-agonists, resulting in hypertensive reactions and tachyarrhythmias. This is a recognized class concern for MAOIs with adrenergic drugs.
What this interaction means in plain words
Phenelzine and Pirbuterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition increases catecholamine availability and augments adrenergic stimulation.
What to do
Avoid the combination if possible and choose a non-adrenergic alternative. If it is necessary, monitor blood pressure and heart rate closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Phenelzine and Pirbuterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Phenelzine with Pirbuterol?
MediHelp rates the interaction as major. Phenelzine and Pirbuterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenelzine can potentiate the cardiovascular effects of sympathomimetic beta-agonists, resulting in hypertensive reactions and tachyarrhythmias. This is a recognized class concern for MAOIs with adrenergic drugs.
How serious is the interaction between Phenelzine and Pirbuterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and choose a non-adrenergic alternative. If it is necessary, monitor blood pressure and heart rate closely.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
