Drug interactions
Phenelzine + Remimazolam
Severity: Moderate
Phenelzine and Remimazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam is a benzodiazepine sedative and phenelzine has additive CNS depressant potential. Together they may increase the depth and duration of sedation and risk of respiratory depression. Hypotension may also be more pronounced.
What this interaction means in plain words
Phenelzine and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenelzine belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and MAOI-related CNS effects.
What to do
Titrate remimazolam carefully to effect and monitor vital signs and oxygenation continuously during sedation and recovery. Ensure airway support and resuscitation equipment are available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Remimazolam
Frequently asked questions
Can I take Phenelzine with Remimazolam?
MediHelp rates the interaction as moderate. Phenelzine and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Remimazolam is a benzodiazepine sedative and phenelzine has additive CNS depressant potential. Together they may increase the depth and duration of sedation and risk of respiratory depression. Hypotension may also be more pronounced.
How serious is the interaction between Phenelzine and Remimazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully to effect and monitor vital signs and oxygenation continuously during sedation and recovery. Ensure airway support and resuscitation equipment are available.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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