Drug interactions
Phenelzine + Same
Severity: Major
Phenelzine and Same: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) may increase serotonergic activity, and with an MAOI this can lead to serotonin syndrome.
What this interaction means in plain words
Phenelzine and Same can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effects, with reduced serotonin breakdown from MAO inhibition.
What to do
Avoid the combination and tell patients to stop SAMe supplements before starting phenelzine. Monitor for serotonin toxicity if exposure occurred.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Phenelzine with Same?
MediHelp rates the interaction as major. Phenelzine and Same can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. S-adenosylmethionine (SAMe) may increase serotonergic activity, and with an MAOI this can lead to serotonin syndrome.
How serious is the interaction between Phenelzine and Same?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and tell patients to stop SAMe supplements before starting phenelzine. Monitor for serotonin toxicity if exposure occurred.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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