Drug interactions
Phenelzine + Serdexmethylphenidate / dexmethylphenidate
Severity: Contraindicated
Phenelzine and Serdexmethylphenidate / dexmethylphenidate: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This methylphenidate-class stimulant increases dopamine and norepinephrine, and MAO inhibition prevents their breakdown. Hypertensive crisis can result, and labeling contraindicates use during or within 14 days of an MAOI.
What this interaction means in plain words
Phenelzine and Serdexmethylphenidate / dexmethylphenidate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Stimulant-induced catecholamine release and reuptake blockade is potentiated by irreversible MAO inhibition.
What to do
Do not coadminister; separate by at least 14 days after stopping phenelzine. Consider non-stimulant ADHD treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Phenelzine with Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates the interaction as contraindicated. Phenelzine and Serdexmethylphenidate / dexmethylphenidate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This methylphenidate-class stimulant increases dopamine and norepinephrine, and MAO inhibition prevents their breakdown. Hypertensive crisis can result, and labeling contraindicates use during or within 14 days of an MAOI.
How serious is the interaction between Phenelzine and Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; separate by at least 14 days after stopping phenelzine. Consider non-stimulant ADHD treatment.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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