Drug interactions
Phenelzine + Sufentanil sl
Severity: Major
Phenelzine and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sublingual sufentanil with an MAOI may lead to serotonin syndrome or opioid toxicity such as respiratory depression and coma. Labeling advises against use during or within 14 days of MAOI therapy.
What this interaction means in plain words
Phenelzine and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Serotonergic excess and potentiated opioid CNS depression with MAO inhibition.
What to do
Avoid unless no alternative exists. If urgent analgesia is needed, use small titrated doses and monitor blood pressure, respiration and mental status closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Phenelzine with Sufentanil sl?
MediHelp rates the interaction as major. Phenelzine and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sublingual sufentanil with an MAOI may lead to serotonin syndrome or opioid toxicity such as respiratory depression and coma. Labeling advises against use during or within 14 days of MAOI therapy.
How serious is the interaction between Phenelzine and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless no alternative exists. If urgent analgesia is needed, use small titrated doses and monitor blood pressure, respiration and mental status closely.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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