Drug interactions
Phenelzine + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Phenelzine and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a long-acting beta2 agonist, and MAOIs may potentiate its cardiovascular effects. This could produce tachycardia, hypertension or arrhythmia.
What this interaction means in plain words
Phenelzine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-agonist stimulation augmented by increased catecholamine availability from MAO inhibition.
What to do
Use with close monitoring of heart rate and blood pressure, especially at start and within 2 weeks of stopping phenelzine. Consider an alternative inhaler if cardiovascular effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Phenelzine with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Phenelzine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a long-acting beta2 agonist, and MAOIs may potentiate its cardiovascular effects. This could produce tachycardia, hypertension or arrhythmia.
How serious is the interaction between Phenelzine and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use with close monitoring of heart rate and blood pressure, especially at start and within 2 weeks of stopping phenelzine. Consider an alternative inhaler if cardiovascular effects occur.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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