Drug interactions
Phenindione + Prednisolone
Severity: Moderate
Phenindione and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can alter the anticoagulant effect of vitamin K antagonists unpredictably, either reducing or increasing it. High doses also raise the risk of gastrointestinal bleeding and vascular fragility.
What this interaction means in plain words
Phenindione and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroids have variable effects on coagulation and vascular integrity, and the exact interaction mechanism is not well established.
What to do
Monitor INR more often when starting, stopping or changing the steroid dose, and adjust the phenindione dose accordingly. Watch for signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Phenindione with Prednisolone?
MediHelp rates the interaction as moderate. Phenindione and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can alter the anticoagulant effect of vitamin K antagonists unpredictably, either reducing or increasing it. High doses also raise the risk of gastrointestinal bleeding and vascular fragility.
How serious is the interaction between Phenindione and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more often when starting, stopping or changing the steroid dose, and adjust the phenindione dose accordingly. Watch for signs of bleeding.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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