Drug interactions
Phenindione + Triamcinolone
Severity: Moderate
Phenindione and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can alter the response to oral anticoagulants, either reducing the effect or raising bleeding risk through effects on vascular integrity and the gastric mucosa. The direction of change is unpredictable, so anticoagulant control may be disturbed.
What this interaction means in plain words
Phenindione and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Unpredictable pharmacodynamic effects of corticosteroids on coagulation, vascular fragility and GI mucosa; the exact mechanism is not well established.
What to do
Check INR more often when starting, changing or stopping triamcinolone, and adjust the phenindione dose accordingly. Watch for signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Frequently asked questions
Can I take Phenindione with Triamcinolone?
MediHelp rates the interaction as moderate. Phenindione and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can alter the response to oral anticoagulants, either reducing the effect or raising bleeding risk through effects on vascular integrity and the gastric mucosa. The direction of change is unpredictable, so anticoagulant control may be disturbed.
How serious is the interaction between Phenindione and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR more often when starting, changing or stopping triamcinolone, and adjust the phenindione dose accordingly. Watch for signs of bleeding.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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