Drug interactions
Phenobarbital + Rasagiline
Severity: Minor
Phenobarbital and Rasagiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is an enzyme inducer that may increase CYP1A2-mediated clearance of rasagiline. This may lower rasagiline levels and reduce its efficacy.
What this interaction means in plain words
Phenobarbital and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Phenobarbital induces CYP1A2, increasing rasagiline metabolism.
What to do
Monitor parkinsonian symptom control when phenobarbital is started or stopped. Increase the rasagiline dose within labeled limits if efficacy declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Phenobarbital with Rasagiline?
MediHelp rates the interaction as minor. Phenobarbital and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenobarbital is an enzyme inducer that may increase CYP1A2-mediated clearance of rasagiline. This may lower rasagiline levels and reduce its efficacy.
How serious is the interaction between Phenobarbital and Rasagiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor parkinsonian symptom control when phenobarbital is started or stopped. Increase the rasagiline dose within labeled limits if efficacy declines.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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