Drug interactions
Phenobarbital + Rocuronium
Severity: Minor
Phenobarbital and Rocuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic phenobarbital therapy may reduce the response to rocuronium, with shorter duration of block and higher dose needs. The magnitude varies between patients.
What this interaction means in plain words
Phenobarbital and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Enzyme induction increasing hepatic clearance of rocuronium, possibly with altered receptor sensitivity.
What to do
Monitor neuromuscular blockade with train-of-four and adjust rocuronium dosing to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rocuronium
Frequently asked questions
Can I take Phenobarbital with Rocuronium?
MediHelp rates the interaction as minor. Phenobarbital and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic phenobarbital therapy may reduce the response to rocuronium, with shorter duration of block and higher dose needs. The magnitude varies between patients.
How serious is the interaction between Phenobarbital and Rocuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular blockade with train-of-four and adjust rocuronium dosing to effect.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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