Drug interactions
Phenobarbital + Ropinirole
Severity: Moderate
Phenobarbital and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is an enzyme inducer and may lower ropinirole concentrations. Symptom control may weaken, particularly after starting phenobarbital or increasing its dose.
What this interaction means in plain words
Phenobarbital and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of hepatic CYP enzymes, including CYP1A2, increases ropinirole metabolism.
What to do
Monitor motor or restless legs symptoms and increase the ropinirole dose if response falls. Reduce it again if phenobarbital is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Phenobarbital with Ropinirole?
MediHelp rates the interaction as moderate. Phenobarbital and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital is an enzyme inducer and may lower ropinirole concentrations. Symptom control may weaken, particularly after starting phenobarbital or increasing its dose.
How serious is the interaction between Phenobarbital and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor or restless legs symptoms and increase the ropinirole dose if response falls. Reduce it again if phenobarbital is withdrawn.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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