Drug interactions
Phenobarbital + Sorafenib
Severity: Moderate
Phenobarbital and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces CYP3A4 and other enzymes and may lower sorafenib concentrations, which could reduce its antitumor effect. Sorafenib is also cleared by UGT1A9, so the reduction may be modest.
What this interaction means in plain words
Phenobarbital and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzyme induction by phenobarbital increases sorafenib metabolism.
What to do
Use a non-inducing anticonvulsant if possible. If it is required, monitor tumor response and consider whether sorafenib dosing needs adjusting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Frequently asked questions
Can I take Phenobarbital with Sorafenib?
MediHelp rates the interaction as moderate. Phenobarbital and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital induces CYP3A4 and other enzymes and may lower sorafenib concentrations, which could reduce its antitumor effect. Sorafenib is also cleared by UGT1A9, so the reduction may be modest.
How serious is the interaction between Phenobarbital and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing anticonvulsant if possible. If it is required, monitor tumor response and consider whether sorafenib dosing needs adjusting.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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