Drug interactions
Phenoxybenzamine + Ramipril
Severity: Moderate
Phenoxybenzamine and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine is a long-acting alpha-blocker, and with ramipril it can cause an exaggerated hypotensive response, especially after the first doses. Orthostatic hypotension and syncope are the main concerns.
What this interaction means in plain words
Phenoxybenzamine and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and blood pressure lowering through pharmacodynamic synergism.
What to do
Start with low doses, titrate gradually and monitor supine and standing blood pressure. Reduce the dose of either drug if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Phenoxybenzamine with Ramipril?
MediHelp rates the interaction as moderate. Phenoxybenzamine and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine is a long-acting alpha-blocker, and with ramipril it can cause an exaggerated hypotensive response, especially after the first doses. Orthostatic hypotension and syncope are the main concerns.
How serious is the interaction between Phenoxybenzamine and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses, titrate gradually and monitor supine and standing blood pressure. Reduce the dose of either drug if symptomatic hypotension occurs.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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