Drug interactions
Phenoxybenzamine + Salmeterol
Severity: Moderate
Phenoxybenzamine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine blocks alpha-adrenergic receptors while salmeterol causes beta-2 mediated vasodilation, which can lead to hypotension with reflex tachycardia. The effect is more pronounced with higher doses or in volume-depleted patients.
What this interaction means in plain words
Phenoxybenzamine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilatory effects from alpha blockade and beta-2 agonism, with reflex tachycardia.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug, and counsel patients about dizziness on standing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Phenoxybenzamine with Salmeterol?
MediHelp rates the interaction as moderate. Phenoxybenzamine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine blocks alpha-adrenergic receptors while salmeterol causes beta-2 mediated vasodilation, which can lead to hypotension with reflex tachycardia. The effect is more pronounced with higher doses or in volume-depleted patients.
How serious is the interaction between Phenoxybenzamine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug, and counsel patients about dizziness on standing.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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