Drug interactions
Phenytoin + Somapacitan
Severity: Minor
Phenytoin and Somapacitan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase cytochrome P450 activity, which could lower phenytoin concentrations. The effect is predicted rather than well documented for phenytoin.
What this interaction means in plain words
Phenytoin and Somapacitan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Phenytoin belongs to Central Nervous System; Somapacitan belongs to Endocrine.
Why it happens
Growth hormone may induce CYP-mediated metabolism, increasing phenytoin clearance.
What to do
Check phenytoin levels and seizure control after starting or changing somapacitan dosing, and adjust the phenytoin dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Phenytoin with Somapacitan?
MediHelp rates the interaction as minor. Phenytoin and Somapacitan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase cytochrome P450 activity, which could lower phenytoin concentrations. The effect is predicted rather than well documented for phenytoin.
How serious is the interaction between Phenytoin and Somapacitan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check phenytoin levels and seizure control after starting or changing somapacitan dosing, and adjust the phenytoin dose if needed.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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