Drug interactions
Pimavanserin + Sufentanil sl
Severity: Moderate
Pimavanserin and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with other CNS depressants can cause profound sedation, respiratory depression, hypotension and death. Pimavanserin can cause somnolence, so additive effects with sublingual sufentanil are possible, although its sedative effect is generally modest.
What this interaction means in plain words
Pimavanserin and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression.
What to do
Use the lowest effective sufentanil dose and monitor for sedation and respiratory depression, particularly after dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Pimavanserin with Sufentanil sl?
MediHelp rates the interaction as moderate. Pimavanserin and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids combined with other CNS depressants can cause profound sedation, respiratory depression, hypotension and death. Pimavanserin can cause somnolence, so additive effects with sublingual sufentanil are possible, although its sedative effect is generally modest.
How serious is the interaction between Pimavanserin and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective sufentanil dose and monitor for sedation and respiratory depression, particularly after dose changes.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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