Drug interactions
Pimozide + Pitolisant
Severity: Major
Pimozide and Pitolisant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant can prolong the QT interval, and pimozide is a potent QT-prolonging agent. Combined use raises the risk of torsades de pointes.
What this interaction means in plain words
Pimozide and Pitolisant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pimozide belongs to Central Nervous System; Pitolisant belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Avoid combination and choose alternatives. If it cannot be avoided, obtain baseline and follow-up ECGs and correct electrolyte abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Pimozide with Pitolisant?
MediHelp rates the interaction as major. Pimozide and Pitolisant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pitolisant can prolong the QT interval, and pimozide is a potent QT-prolonging agent. Combined use raises the risk of torsades de pointes.
How serious is the interaction between Pimozide and Pitolisant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination and choose alternatives. If it cannot be avoided, obtain baseline and follow-up ECGs and correct electrolyte abnormalities.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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