Drug interactions
Pimozide + Safinamide
Severity: Major
Pimozide and Safinamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide blocks dopamine D2 receptors and opposes the effect of safinamide in Parkinson disease, potentially worsening motor symptoms.
What this interaction means in plain words
Pimozide and Safinamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pimozide belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between D2 receptor blockade and dopaminergic therapy.
What to do
Avoid pimozide in Parkinson disease. Use an antipsychotic with less D2 blockade and monitor motor status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Pimozide with Safinamide?
MediHelp rates the interaction as major. Pimozide and Safinamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pimozide blocks dopamine D2 receptors and opposes the effect of safinamide in Parkinson disease, potentially worsening motor symptoms.
How serious is the interaction between Pimozide and Safinamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pimozide in Parkinson disease. Use an antipsychotic with less D2 blockade and monitor motor status.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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