Drug interactions
Pimozide + Scopolamine
Severity: Moderate
Pimozide and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide has some anticholinergic activity and causes sedation, so scopolamine can add to dry mouth, constipation, urinary retention and confusion. Pimozide also prolongs the QT interval, but scopolamine is not known to affect that risk, so the main concern is the anticholinergic burden.
What this interaction means in plain words
Pimozide and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimozide belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade and CNS depression.
What to do
Monitor for anticholinergic effects and sedation. Reduce the dose of one drug if symptoms are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pimozide with Scopolamine?
MediHelp rates the interaction as moderate. Pimozide and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide has some anticholinergic activity and causes sedation, so scopolamine can add to dry mouth, constipation, urinary retention and confusion. Pimozide also prolongs the QT interval, but scopolamine is not known to affect that risk, so the main concern is the anticholinergic burden.
How serious is the interaction between Pimozide and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and sedation. Reduce the dose of one drug if symptoms are troublesome.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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