Drug interactions
Pimozide + Selegiline
Severity: Moderate
Pimozide and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO-B inhibitor, which at higher doses loses selectivity, and dopamine agonism opposes pimozide's dopamine blockade. Pimozide may reduce the antiparkinsonian benefit of selegiline and worsen parkinsonism, while serotonergic reactions are possible but uncommon.
What this interaction means in plain words
Pimozide and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimozide belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between dopamine blockade and dopaminergic enhancement, with possible serotonergic effects.
What to do
Avoid in Parkinson's disease where possible. Otherwise monitor motor symptoms, mental status and temperature.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Pimozide with Selegiline?
MediHelp rates the interaction as moderate. Pimozide and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline is an MAO-B inhibitor, which at higher doses loses selectivity, and dopamine agonism opposes pimozide's dopamine blockade. Pimozide may reduce the antiparkinsonian benefit of selegiline and worsen parkinsonism, while serotonergic reactions are possible but uncommon.
How serious is the interaction between Pimozide and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in Parkinson's disease where possible. Otherwise monitor motor symptoms, mental status and temperature.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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