Drug interactions
Pimozide + Somatrogon
Severity: Minor
Pimozide and Somatrogon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone products may increase CYP450-mediated drug clearance, which could lower exposure to CYP3A4 substrates like pimozide. The result may be reduced control of tics, though supporting data are limited.
What this interaction means in plain words
Pimozide and Somatrogon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pimozide belongs to Central Nervous System; Somatrogon belongs to Endocrine.
Why it happens
Growth hormone may induce CYP450 activity, modestly increasing the metabolism of CYP3A4 substrates.
What to do
Monitor tic control when somatrogon is started or stopped and titrate pimozide to response. Check ECG when raising the pimozide dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Pimozide with Somatrogon?
MediHelp rates the interaction as minor. Pimozide and Somatrogon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone products may increase CYP450-mediated drug clearance, which could lower exposure to CYP3A4 substrates like pimozide. The result may be reduced control of tics, though supporting data are limited.
How serious is the interaction between Pimozide and Somatrogon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tic control when somatrogon is started or stopped and titrate pimozide to response. Check ECG when raising the pimozide dose.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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