Drug interactions
Pimozide + Sotorasib
Severity: Moderate
Pimozide and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a CYP3A4 inducer and may lower pimozide concentrations, reducing efficacy. The narrow therapeutic window of pimozide makes this problematic.
What this interaction means in plain words
Pimozide and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimozide belongs to Central Nervous System; Sotorasib belongs to Oncology.
Why it happens
CYP3A4 induction by sotorasib increases pimozide metabolism.
What to do
Avoid if possible; otherwise monitor clinical response and ECG and adjust pimozide cautiously. Reassess the dose when sotorasib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Pimozide with Sotorasib?
MediHelp rates the interaction as moderate. Pimozide and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a CYP3A4 inducer and may lower pimozide concentrations, reducing efficacy. The narrow therapeutic window of pimozide makes this problematic.
How serious is the interaction between Pimozide and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor clinical response and ECG and adjust pimozide cautiously. Reassess the dose when sotorasib is stopped.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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