Drug interactions
Pindolol + Salmeterol
Severity: Major
Pindolol and Salmeterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pindolol is a non-selective beta-blocker that can blunt the bronchodilator effect of salmeterol and may precipitate bronchospasm in patients with reactive airway disease. Its partial agonist activity does not reliably prevent this.
What this interaction means in plain words
Pindolol and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors by a non-selective beta-blocker.
What to do
Avoid in patients with asthma or COPD who need salmeterol; if a beta-blocker is required, use a cardioselective agent and monitor respiratory status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Pindolol with Salmeterol?
MediHelp rates the interaction as major. Pindolol and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pindolol is a non-selective beta-blocker that can blunt the bronchodilator effect of salmeterol and may precipitate bronchospasm in patients with reactive airway disease. Its partial agonist activity does not reliably prevent this.
How serious is the interaction between Pindolol and Salmeterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with asthma or COPD who need salmeterol; if a beta-blocker is required, use a cardioselective agent and monitor respiratory status.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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