Drug interactions
Pindolol + Tolmetin
Severity: Moderate
Pindolol and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolmetin can reduce the blood pressure lowering effect of beta-blockers, especially with continued use beyond about a week. Pindolol may be affected less than other beta-blockers, but loss of control is still possible.
What this interaction means in plain words
Pindolol and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium and water retention oppose the antihypertensive action of the beta-blocker.
What to do
Monitor blood pressure during prolonged tolmetin use and adjust antihypertensive dosing if required. Keep the NSAID dose and duration as low as possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Pindolol with Tolmetin?
MediHelp rates the interaction as moderate. Pindolol and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolmetin can reduce the blood pressure lowering effect of beta-blockers, especially with continued use beyond about a week. Pindolol may be affected less than other beta-blockers, but loss of control is still possible.
How serious is the interaction between Pindolol and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during prolonged tolmetin use and adjust antihypertensive dosing if required. Keep the NSAID dose and duration as low as possible.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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