Drug interactions
Pioglitazone + Quinupristin / dalfopristin
Severity: Minor
Pioglitazone and Quinupristin / dalfopristin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and could raise pioglitazone levels. Because pioglitazone is cleared mainly by CYP2C8, the effect is probably small and the combination is short-term.
What this interaction means in plain words
Pioglitazone and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 reduces part of pioglitazone metabolism.
What to do
Monitor blood glucose during the antibiotic course and watch for edema or hypoglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pioglitazone
Frequently asked questions
Can I take Pioglitazone with Quinupristin / dalfopristin?
MediHelp rates the interaction as minor. Pioglitazone and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinupristin/dalfopristin inhibits CYP3A4 and could raise pioglitazone levels. Because pioglitazone is cleared mainly by CYP2C8, the effect is probably small and the combination is short-term.
How serious is the interaction between Pioglitazone and Quinupristin / dalfopristin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the antibiotic course and watch for edema or hypoglycemia.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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