Drug interactions
Piperacillin-tazobactam + Streptomycin
Severity: Moderate
Piperacillin-tazobactam and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination can be synergistic against some bacteria, but piperacillin may inactivate aminoglycosides, particularly in renal impairment. Aminoglycoside oto- and nephrotoxicity remain a concern.
What this interaction means in plain words
Piperacillin-tazobactam and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Piperacillin-tazobactam belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Why it happens
Pharmacodynamic synergy, plus possible chemical inactivation of the aminoglycoside by the penicillin.
What to do
Administer separately and do not mix in one container. Monitor streptomycin levels, renal function and auditory or vestibular symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piperacillin-tazobactam
Other interactions of Streptomycin
Frequently asked questions
Can I take Piperacillin-tazobactam with Streptomycin?
MediHelp rates the interaction as moderate. Piperacillin-tazobactam and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination can be synergistic against some bacteria, but piperacillin may inactivate aminoglycosides, particularly in renal impairment. Aminoglycoside oto- and nephrotoxicity remain a concern.
How serious is the interaction between Piperacillin-tazobactam and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Administer separately and do not mix in one container. Monitor streptomycin levels, renal function and auditory or vestibular symptoms.
What other medicines interact with Piperacillin-tazobactam?
MediHelp also lists interactions of Piperacillin-tazobactam with, for example, Vancomycin, Amikacin, Antithrombin alfa. The full list is on the Piperacillin-tazobactam page.
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