Drug interactions
Pirbuterol + Promethazine
Severity: Minor
Pirbuterol and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirbuterol is an inhaled beta-2 agonist that can cause stimulation, tremor and tachycardia, whereas promethazine is sedating. No consistent clinically important interaction is established.
What this interaction means in plain words
Pirbuterol and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible opposing CNS effects; no established pharmacokinetic interaction.
What to do
No specific action is needed beyond monitoring heart rate in patients with cardiac disease. Treat bronchospasm as clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Pirbuterol with Promethazine?
MediHelp rates the interaction as minor. Pirbuterol and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pirbuterol is an inhaled beta-2 agonist that can cause stimulation, tremor and tachycardia, whereas promethazine is sedating. No consistent clinically important interaction is established.
How serious is the interaction between Pirbuterol and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond monitoring heart rate in patients with cardiac disease. Treat bronchospasm as clinically indicated.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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