Drug interactions
Pirfenidone + Somatropin
Severity: Minor
Pirfenidone and Somatropin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may induce CYP1A2 activity, which could reduce pirfenidone exposure because CYP1A2 is its main metabolic pathway. The effect is theoretical, with little clinical data.
What this interaction means in plain words
Pirfenidone and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pirfenidone belongs to Miscellaneous; Somatropin belongs to Endocrine.
Why it happens
Possible growth hormone-mediated induction of CYP1A2.
What to do
No routine adjustment is needed; monitor for reduced pirfenidone efficacy if somatropin is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Other interactions of Pirfenidone
Frequently asked questions
Can I take Pirfenidone with Somatropin?
MediHelp rates the interaction as minor. Pirfenidone and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may induce CYP1A2 activity, which could reduce pirfenidone exposure because CYP1A2 is its main metabolic pathway. The effect is theoretical, with little clinical data.
How serious is the interaction between Pirfenidone and Somatropin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for reduced pirfenidone efficacy if somatropin is started.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
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