Drug interactions
Pitavastatin + Sacubitril-valsartan
Severity: Moderate
Pitavastatin and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sacubitril inhibits OATP1B1 and OATP1B3 in vitro, and sacubitril-valsartan has been shown to raise exposure to some OATP substrate statins such as atorvastatin. Higher statin levels could increase the risk of muscle toxicity, though the effect on pitavastatin is not well characterized.
What this interaction means in plain words
Pitavastatin and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pitavastatin belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake transporters by sacubitril reduces statin hepatic uptake and raises plasma concentrations.
What to do
Monitor for muscle pain, weakness or dark urine and check creatine kinase if symptoms occur. Use the lowest effective pitavastatin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Frequently asked questions
Can I take Pitavastatin with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Pitavastatin and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sacubitril inhibits OATP1B1 and OATP1B3 in vitro, and sacubitril-valsartan has been shown to raise exposure to some OATP substrate statins such as atorvastatin. Higher statin levels could increase the risk of muscle toxicity, though the effect on pitavastatin is not well characterized.
How serious is the interaction between Pitavastatin and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness or dark urine and check creatine kinase if symptoms occur. Use the lowest effective pitavastatin dose.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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