Drug interactions
Pneumococcal vaccine polyvalent + Prednisolone
Severity: Moderate
Pneumococcal vaccine polyvalent and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids may reduce the antibody response to polyvalent pneumococcal vaccine. The vaccine is inactivated and remains recommended for steroid-treated patients.
What this interaction means in plain words
Pneumococcal vaccine polyvalent and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid immunosuppression reduces vaccine-induced antibody production.
What to do
Vaccinate ideally before starting immunosuppression or at the lowest steroid dose. Do not postpone in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Pneumococcal vaccine polyvalent with Prednisolone?
MediHelp rates the interaction as moderate. Pneumococcal vaccine polyvalent and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids may reduce the antibody response to polyvalent pneumococcal vaccine. The vaccine is inactivated and remains recommended for steroid-treated patients.
How serious is the interaction between Pneumococcal vaccine polyvalent and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate ideally before starting immunosuppression or at the lowest steroid dose. Do not postpone in high-risk patients.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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