Drug interactions
Poliovirus vaccine inactivated + Rituximab
Severity: Moderate
Poliovirus vaccine inactivated and Rituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rituximab-induced B-cell depletion blunts antibody responses to inactivated vaccines. Inactivated poliovirus vaccine is safe but may fail to provide protection if given during or soon after rituximab.
What this interaction means in plain words
Poliovirus vaccine inactivated and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
B-cell depletion impairs humoral immune response to vaccine antigens.
What to do
Give the vaccine at least 4 weeks before rituximab where possible, or delay until B-cell recovery, around 6 months after therapy. Consider checking antibody titers when protection is important.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rituximab
Frequently asked questions
Can I take Poliovirus vaccine inactivated with Rituximab?
MediHelp rates the interaction as moderate. Poliovirus vaccine inactivated and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rituximab-induced B-cell depletion blunts antibody responses to inactivated vaccines. Inactivated poliovirus vaccine is safe but may fail to provide protection if given during or soon after rituximab.
How serious is the interaction between Poliovirus vaccine inactivated and Rituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine at least 4 weeks before rituximab where possible, or delay until B-cell recovery, around 6 months after therapy. Consider checking antibody titers when protection is important.
What other medicines interact with Rituximab?
MediHelp also lists interactions of Rituximab with, for example, Adenovirus types 4 and 7 live, Baricitinib, Certolizumab pegol. The full list is on the Rituximab page.
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