Drug interactions
Poliovirus vaccine inactivated + Tocilizumab
Severity: Moderate
Poliovirus vaccine inactivated and Tocilizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tocilizumab may reduce the immune response to inactivated poliovirus vaccine. The vaccine is safe because it is non-live, but protection may be incomplete.
What this interaction means in plain words
Poliovirus vaccine inactivated and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Interleukin-6 receptor blockade impairs B-cell activation and antibody production, reducing vaccine immunogenicity.
What to do
Complete inactivated vaccination before tocilizumab where feasible. If given during treatment, consider revaccination or serological confirmation of immunity afterwards.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Frequently asked questions
Can I take Poliovirus vaccine inactivated with Tocilizumab?
MediHelp rates the interaction as moderate. Poliovirus vaccine inactivated and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tocilizumab may reduce the immune response to inactivated poliovirus vaccine. The vaccine is safe because it is non-live, but protection may be incomplete.
How serious is the interaction between Poliovirus vaccine inactivated and Tocilizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete inactivated vaccination before tocilizumab where feasible. If given during treatment, consider revaccination or serological confirmation of immunity afterwards.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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