Drug interactions
Prabotulinumtoxina + Tobramycin
Severity: Moderate
Prabotulinumtoxina and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can impair neuromuscular transmission and may potentiate botulinum toxin. This may cause excessive weakness, including swallowing and breathing difficulty.
What this interaction means in plain words
Prabotulinumtoxina and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic impairment of neuromuscular transmission.
What to do
Avoid systemic tobramycin around the time of treatment where alternatives exist. If both are needed, monitor for excessive weakness, dysphagia and respiratory difficulty.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Prabotulinumtoxina with Tobramycin?
MediHelp rates the interaction as moderate. Prabotulinumtoxina and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can impair neuromuscular transmission and may potentiate botulinum toxin. This may cause excessive weakness, including swallowing and breathing difficulty.
How serious is the interaction between Prabotulinumtoxina and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic tobramycin around the time of treatment where alternatives exist. If both are needed, monitor for excessive weakness, dysphagia and respiratory difficulty.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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