Drug interactions
Prabotulinumtoxina + Tolterodine
Severity: Moderate
Prabotulinumtoxina and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anticholinergic drugs may add to the effects of botulinum toxins. This could increase systemic anticholinergic effects and, rarely, neuromuscular weakness after toxin injection.
What this interaction means in plain words
Prabotulinumtoxina and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cholinergic blockade at muscarinic receptors and neuromuscular junction.
What to do
Monitor for generalized weakness, swallowing or breathing difficulty and anticholinergic effects after injection. Consider reducing tolterodine if such effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Prabotulinumtoxina with Tolterodine?
MediHelp rates the interaction as moderate. Prabotulinumtoxina and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anticholinergic drugs may add to the effects of botulinum toxins. This could increase systemic anticholinergic effects and, rarely, neuromuscular weakness after toxin injection.
How serious is the interaction between Prabotulinumtoxina and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for generalized weakness, swallowing or breathing difficulty and anticholinergic effects after injection. Consider reducing tolterodine if such effects appear.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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