Drug interactions
Praziquantel + Telotristat ethyl
Severity: Minor
Praziquantel and Telotristat ethyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat may induce CYP3A4 and reduce exposure of CYP3A4 substrates, though the effect on praziquantel is not well characterized. Reduced efficacy is theoretically possible.
What this interaction means in plain words
Praziquantel and Telotristat ethyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 induction by telotristat ethyl increases praziquantel metabolism.
What to do
Usually no change needed; monitor clinical response to praziquantel. Consider separating or short-course use only if efficacy is in doubt.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Frequently asked questions
Can I take Praziquantel with Telotristat ethyl?
MediHelp rates the interaction as minor. Praziquantel and Telotristat ethyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Telotristat may induce CYP3A4 and reduce exposure of CYP3A4 substrates, though the effect on praziquantel is not well characterized. Reduced efficacy is theoretically possible.
How serious is the interaction between Praziquantel and Telotristat ethyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change needed; monitor clinical response to praziquantel. Consider separating or short-course use only if efficacy is in doubt.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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