Drug interactions
Prazosin + Tolmetin
Severity: Moderate
Prazosin and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolmetin can blunt the blood pressure lowering effect of alpha-blockers like prazosin. Sodium and fluid retention together with reduced vasodilatory prostaglandins may lead to loss of blood pressure control.
What this interaction means in plain words
Prazosin and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prazosin belongs to Genitourinary; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and water retention and reduces vasodilation, opposing the antihypertensive effect.
What to do
Monitor blood pressure when tolmetin is started, changed or stopped in a patient taking prazosin. Adjust the antihypertensive dose if control worsens, or use a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Prazosin with Tolmetin?
MediHelp rates the interaction as moderate. Prazosin and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolmetin can blunt the blood pressure lowering effect of alpha-blockers like prazosin. Sodium and fluid retention together with reduced vasodilatory prostaglandins may lead to loss of blood pressure control.
How serious is the interaction between Prazosin and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when tolmetin is started, changed or stopped in a patient taking prazosin. Adjust the antihypertensive dose if control worsens, or use a non-NSAID analgesic.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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