Drug interactions
Prazosin + Trandolapril
Severity: Moderate
Prazosin and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prazosin causes first-dose orthostatic hypotension, and an ACE inhibitor can amplify the blood pressure drop. Dizziness and syncope may occur, especially when either drug is initiated.
What this interaction means in plain words
Prazosin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prazosin belongs to Genitourinary; Trandolapril belongs to Cardiovascular.
Why it happens
Additive vasodilation from alpha-1 blockade and inhibition of the renin-angiotensin system.
What to do
Start prazosin at a low dose at bedtime and monitor standing blood pressure. Advise patients to rise slowly and adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Prazosin with Trandolapril?
MediHelp rates the interaction as moderate. Prazosin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prazosin causes first-dose orthostatic hypotension, and an ACE inhibitor can amplify the blood pressure drop. Dizziness and syncope may occur, especially when either drug is initiated.
How serious is the interaction between Prazosin and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start prazosin at a low dose at bedtime and monitor standing blood pressure. Advise patients to rise slowly and adjust doses if symptomatic hypotension occurs.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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