Drug interactions
Prednisolone + Radium ra-223 dichloride
Severity: Major
Prednisolone and Radium ra-223 dichloride: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisolone given as part of abiraterone therapy with radium-223 was associated with more fractures and deaths. Corticosteroids themselves reduce bone density, so skeletal risk may be compounded.
What this interaction means in plain words
Prednisolone and Radium ra-223 dichloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Prednisolone belongs to Endocrine; Radium ra-223 dichloride belongs to Oncology.
Why it happens
The mechanism is not fully established; additive skeletal toxicity is suspected, including corticosteroid-induced bone loss.
What to do
Avoid using radium-223 with abiraterone plus prednisolone outside trials; assess fracture risk and consider bone-protective therapy when steroids are required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Radium ra-223 dichloride
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Prednisolone with Radium ra-223 dichloride?
MediHelp rates the interaction as major. Prednisolone and Radium ra-223 dichloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prednisolone given as part of abiraterone therapy with radium-223 was associated with more fractures and deaths. Corticosteroids themselves reduce bone density, so skeletal risk may be compounded.
How serious is the interaction between Prednisolone and Radium ra-223 dichloride?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using radium-223 with abiraterone plus prednisolone outside trials; assess fracture risk and consider bone-protective therapy when steroids are required.
What other medicines interact with Radium ra-223 dichloride?
MediHelp also lists interactions of Radium ra-223 dichloride with, for example, Abiraterone, Prednisone. The full list is on the Radium ra-223 dichloride page.
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