Drug interactions
Prednisolone + Salicylates
Severity: Moderate
Prednisolone and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with salicylates increase the risk of gastric irritation, ulceration and bleeding. Corticosteroids may also lower salicylate levels.
What this interaction means in plain words
Prednisolone and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury; corticosteroids can increase renal salicylate clearance.
What to do
Consider gastroprotection with a proton pump inhibitor in at-risk patients and monitor for GI bleeding. Watch salicylate effect if the steroid is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Prednisolone with Salicylates?
MediHelp rates the interaction as moderate. Prednisolone and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with salicylates increase the risk of gastric irritation, ulceration and bleeding. Corticosteroids may also lower salicylate levels.
How serious is the interaction between Prednisolone and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection with a proton pump inhibitor in at-risk patients and monitor for GI bleeding. Watch salicylate effect if the steroid is stopped.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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