Drug interactions
Prednisolone + Tetanus toxoid adsorbed or fluid
Severity: Minor
Prednisolone and Tetanus toxoid adsorbed or fluid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids may reduce the antibody response to tetanus toxoid. The vaccine is not live, so vaccination remains appropriate.
What this interaction means in plain words
Prednisolone and Tetanus toxoid adsorbed or fluid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glucocorticoid immunosuppression modestly reduces vaccine-induced antibody production.
What to do
Vaccinate as indicated without delay. In a tetanus-prone wound in a heavily immunosuppressed patient, also consider tetanus immune globulin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Prednisolone with Tetanus toxoid adsorbed or fluid?
MediHelp rates the interaction as minor. Prednisolone and Tetanus toxoid adsorbed or fluid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids may reduce the antibody response to tetanus toxoid. The vaccine is not live, so vaccination remains appropriate.
How serious is the interaction between Prednisolone and Tetanus toxoid adsorbed or fluid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as indicated without delay. In a tetanus-prone wound in a heavily immunosuppressed patient, also consider tetanus immune globulin.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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